Find materials for this course in the pages linked along the left. Bacteria are everywherebacteria are everywhere bacteria are singlecelled organisms that grow ilti lldliin populations called colonies. Platensimycin was identified as a metabolite of a filamentous bacterium streptomyces platensis ma7327 strain found in soil samples from spain and south africa in 2006. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. I taught this to midlow ability but worksheet could be left blank rather than fill in the blanks for. Platensimycin, a metabolite of streptomyces platensis, which is an excellent example of a unique structural class of natural antibiotics, has been demonstrated to be a breakthrough in recent antibiotic research due to its unique functional pattern and significant antibacterial activity. This compound is a member of a class of antibiotics which act by blocking enzymes involved in the. Coordinating development of new antimicrobials and. Power point and worksheet for teaching yr8 antibiotics. People can view the slides even if they dont have powerpoint, but they cant make changes to it. Optional to select a video frame to use as a poster, drag the slider to the frame and click set poster image from. An enantioselective route to the tetracyclic core structure of the novel antibiotic lead compound platensimycin is accomplished in 10 steps from simple commercially available starting materials. Microsoft powerpoint quick view taxol is a potent anticancer agent. It is assumed that fewer bacteria build a resistance against platensimycin, which provides platensimycin to be a possible reserve antibiotic.
Welcome to sagefox free powerpoint templates one of the most useful and unique powerpoint templates resource websites available. Customary urine test is the dip stick and the midstream culture of voided urine. Tes global ltd is registered in england company no 02017289 with its registered office at 26 red lion square london wc1r 4hq. The use of antibiotics is the single most important factor leading to antibiotic resistance. In some countries, this medicine may only be approved for veterinary use.
They can express a variety of different kinds of chemical reactivity. Platensimycin ptm and platencin ptn are potent inhibitors of bacterial fatty acid synthases. Choose a multimedia file from the menu, or click browse to locate and select the file. Muhammad saleem, hidayat hussain, ishtiaq ahmed, teunis van ree and karsten krohn, platensimycin and its relatives. In a subsequent study, threestep isolation was modified by singh et al. Mechanisms of selfresistance in the platensimycin and. In the publish as pdf or xps dialog box, choose a location to save the file to. Objectives platensimycin ptm is a natural antibiotic produced by streptomyces platensis that selectively inhibits bacterial and mammalian fatty acid synthase fas without affecting synthesis of other lipids.
Platensimycin 71 and platencin 72 are produced by various strains of streptomyces platensis. Prophylactic antibiotics are recommended for high risk contacts. We provide you a huge collection of 12686 free themed powerpoint templates that you can download for free, and. Discovered antibiotic, penicillin the story of penicillin a chemical substance derivable from a mold or bacterium that kills microorganisms and cures infections zdefinition of antibiotic. Platensimycin ptm platencin ptn oo o o n h oh ho 2c ho 2c opp ggdp entcdp entatiserene entkauran16ol ptmt2 ptmt3 ptmt1 ptnt1 ptnt2 figure 8.
This compound is a member of a class of antibiotics which act by blocking enzymes involved in the condensation steps in fatty acid biosynthesis, which grampositive bacteria need to biosynthesise cell membranes. Click create pdf xps document, then click create pdf xps. This website and its content is subject to our terms and conditions. Systematic screening of natural product extracts, using a combination of targetbased wholecell antisense and biochemical assays, led to the identification of an antibacterial agent, platensimycin, from a strain of s. Convert and create pdf from various types of files like word doc, excel xls, powerpoint ppt. A recent story in the struggle to develop new naturally derived antibiotics, natural product reports, 10. Miller, phd, dabmm, faam chair, asm committee on laboratory practices. Chemistry 259 medicinal chemistry of modern antibiotics. However, ive spent enough time looking at his work in this area, so its a pleasure to examine this synthesis by jon njar. Ptmp3ptnp3 confer resistance by target replacement, while fabf confers resistance by.
Up to 50% of all antibiotics prescribed are not needed or are not optimally effective as prescribed. The use of platensimycin and platencin to fight antibiotic. Ppt antibiotics and antibiotic resistance powerpoint. Planning a synthesis by going in reverse i can make that. Download as ppt, pdf, txt or read online from scribd. Co, md, fpps, fpsecp professorial lecturer in antimicrobial therapy, graduate school university of santo tomas executive director, center for drug research evaluation and studies, inc. Pdf converter is a online webbased document to pdf converter software.
Scribd is the worlds largest social reading and publishing site. Naturally occurring unique class of natural antibiotic, platensimycin, a secondary metabolite from streptomyces platensis, is an excellent breakthrough in recent antibiotic research with unique structural pattern and significant antibacterial activity. Cadmium epidemicscase studies japan 1950s itaiita i is japanese for ouchouch refers to bone pain related to calcium loss renal failure,anemia, severe muscle pain river polluted with waste from factory, water used on rice fields for many years rice accumulated high level of cd community was poor and therefore malnourished with respect to. O oh o o ohoh o oh o o o o o ro o claisen 1 3 2 1 3 2 1 3 2 aldol red. Penicillins as well as cephalosporins are called betalactam antibiotics and are characterized by three fundamental structural requirements. Paul ehrlich proposed idea of using a drug that would selectively find and kill. Discovery of platencin, a dual fabf and fabh inhibitor.
To embed multimedia files into powerpoint documents, you need have pdfmaker installed. Twice in as many weeks, too, as kc has decided to drop the details on his many syntheses of platensimycin and platensin into a full jacs paper. Introduction carbonyl compounds exist in equilibrium with their tautomers, which are enols. Common pathogens bordetella pertussis respiratory continued over page respiratory 1. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Coordinating development of new antimicrobials and susceptibility testing methods melissa b. These tables are supplements to the corresponding compilations in previous volumes of the alkaloids academic press 3,4 recent papers have shown that solanum species often contain. Chemistry 259 medicinal chemistry of modern antibiotics spring 2008 lecture 7. Platensimycin and platencin biosynthesis in streptomyces. When you save presentation as a pdf file it freezes the formatting and layout. Emerging resistance to existing antibiotics is an inevitable matter of concern in the treatment of bacterial infection. In the us, panmycin tetracycline systemic is a member of the drug class tetracyclines and is used to treat acne, bacterial infection, bladder infection, bronchitis, brucellosis, bullous pemphigoid, chlamydia infection, ehrlichiosis, epididymitis sexually transmitted, gonococcal infection uncomplicated. Platensimycin is a member of a previously unknown class of antibiotics, which acts by blocking enzymes involved in the of the condensation steps in fatty acid biosynthesis, which bacteria need to biosynthesise cell membranes. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect.
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